Mixed chimaerism; detection and significance following BMT

TitleMixed chimaerism; detection and significance following BMT
Publication TypeJournal Article
Year of Publication1993
AuthorsMcCann SR, Lawler M
JournalBone Marrow Transplant
Pagination91 - 4
Date PublishedFeb
Accession Number8435668
Keywords*Chimera, Anemia, Aplastic / pathology / surgery, Bone Marrow Purging, Bone Marrow Transplantation / *pathology, Graft Survival, Hematopoietic Stem Cells / pathology, Humans, Leukemia / pathology / surgery, Research Support, Non-U.S. Gov't, Tumor Stem Cells / pathology

Residual recipient haematopoietic cells may coexist with donor haemopoietic tissue following BMT. This is known as mixed chimaerism. The incidence of mixed chimaerism varies with the sensitivity of the detection system used; DNA based methodologies are the most sensitive. The influence of mixed chimaerism on leukaemia relapse and graft rejection is unclear. The lineages in which mixed chimaerism occurs may affect outcome.

Notify Library Reference ID982

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