Acute life-threatening cardiovascular toxicity with umbilical cord blood infusion: the role of dextran.

TitleAcute life-threatening cardiovascular toxicity with umbilical cord blood infusion: the role of dextran.
Publication TypeJournal Article
Year of Publication2010
AuthorsMa RW, Kwan JM, Ma DD, Fay KC
JournalAm J Hematol
Volume85
Issue9
Pagination722 - 4
Date PublishedSep
ISSN1096-8652
Accession Number20661918
KeywordsAdult, Aged, Cord Blood Stem Cell Transplantation, Dextrans, Female, Hematologic Neoplasms, Humans, Male, Middle Aged, Myocardial Ischemia, Plasma Substitutes, Transplantation, Homologous
Abstract

Umbilical cord blood (UCB) is being increasingly used for hematopoietic stem cell transplantation due to its immediate availability. Dimethylsulfoxide (DMSO) and dextran-40 are commonly used for processing and cryopreservation of UCB. Adverse UCB infusion-related events are usually mild. However, reports of severe life-threatening events are now emerging. DMSO has been proposed as a possible cause of infusion-related reactions. In this report, we draw attention to an acute near-fatal reaction with UCB infusions resulting in myocardial ischemia and acute renal failure. We propose that dextran-40 in UCB infusion products be considered as a potential causative agent contributing to this infusion-related reaction, based on reports of known adverse reactions to dextran-40 in non-transplant settings.

DOI10.1002/ajh.21797
Notify Library Reference ID935

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