| Title | [The characteristics of Trypanosoma cruzi strains isolated from patients who have undergone a heart transplant] |
| Publication Type | Journal Article |
| Year of Publication | 1995 |
| Authors | Lanura PN, Matsubara L, Amato Neto V, Okumura M, Bocchi EA |
| Journal | Rev Soc Bras Med Trop |
| Volume | 28 |
| Issue | 4 |
| Pagination | 351 - 6 |
| Date Published | Oct-Dec |
| ISSN | 0037-8682 (Print) 0037-8682 (Linking) |
| Accession Number | 8668835 |
| Keywords | *Heart Transplantation, Adolescent, Adult, Animals, Chagas Cardiomyopathy / parasitology / pathology / surgery, Disease Models, Animal, Feces / parasitology, Female, Humans, Male, Mice, Mice, Inbred BALB C, Parasitemia / parasitology / pathology, Postoperative Period, Time Factors, Trypanosoma cruzi / *isolation & purification / pathogenicity |
| Abstract | Three strains of Trypanosoma cruzi were isolated from Chagas' disease patients transplanted for heart failure, after cardiac transplantation, and were studied in an experimental model of Chagas' disease, in mice, with evaluation of parasitic load, mortality and extension of inflammatory infiltrates in the heart. These parameters were compared with the standard strain Y. The strains had differences in the studied parameters, but there was no clear relationship between those and post-transplant evolution of the patients. Probably the clinical response is multifactorial and derives only in part from biological characteristics of the infecting T. cruzi strain, as measured in our model. |
| Short Title | [The characteristics of Trypanosoma cruzi strains isolated from patients who have undergone a heart transplant] |
| Notify Library Reference ID | 867 |
