Creutzfeldt-Jakob disease via dural and corneal transplants

TitleCreutzfeldt-Jakob disease via dural and corneal transplants
Publication TypeJournal Article
Year of Publication1998
AuthorsLang CJ, Heckmann JG, Neundorfer B
JournalJ Neurol Sci
Pagination128 - 39
Date PublishedOct 8
ISSN0022-510X (Print) 0022-510X (Linking)
Accession Number9849795
KeywordsAdolescent, Adult, Ataxia / etiology, Child, Corneal Transplantation / *adverse effects, Creutzfeldt-Jakob Syndrome / *diagnosis / epidemiology / etiology / *transmission, Dura Mater / *transplantation, Dysarthria / etiology, Female, Human Growth Hormone / adverse effects, Humans, Iatrogenic Disease / epidemiology, Infant, Male, Middle Aged, Myoclonus / etiology

A review of all published cases of iatrogenic Creutzfeldt-Jakob disease (CJD) via dural (N=71) and corneal (N=4) transplants is given. All but three of the dural cases were obviously due to a commercial product recalled in 1996. Two of the corneal grafts were taken from patients who had died of sporadic CJD. These cases differed from CJD due to human growth hormone injections and the new variant. Instead. they were akin to sporadic cases, but memory loss, disorders of higher cerebral functions and extrapyramidal signs were fewer, while cerebellar abnormalities were more frequent. Progressive dysarthria and gait disorder/gait ataxia were prominent signs during the early stages, myocloni the most salient feature later. A nonperiodic EEG did not contradict the diagnosis. Using current diagnostic criteria the disease was underdiagnosed ante mortem. Utmost care is needed in selecting, harvesting and handling dural and corneal grafts to avoid inadvertent transmission of CJD.

URLinternal-pdf://Lang - CJD via corneal transplants-1178861569/Lang - CJD via corneal transplants.pdf
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