Creutzfeldt-Jakob disease in a pregnant woman with an implanted dura mater graft

TitleCreutzfeldt-Jakob disease in a pregnant woman with an implanted dura mater graft
Publication TypeJournal Article
Year of Publication1994
AuthorsLane KL, Brown P, Howell DN, Crain BJ, Hulette CM, Burger PC, DeArmond SJ
Pagination737 - 9; - discussion - 739-40
Date PublishedApr
ISSN0148-396X (Print) 0148-396X (Linking)
Accession Number8008176
KeywordsAdult, Arnold-Chiari Malformation / pathology / *surgery, Atrophy, Brain / pathology, Collagen / *adverse effects, Creutzfeldt-Jakob Syndrome / diagnosis / pathology / *transmission, Female, Humans, Infant, Newborn, Male, Nerve Degeneration / physiology, Neurologic Examination, Postoperative Complications / *diagnosis / pathology, Pregnancy, Pregnancy Complications, Infectious / *diagnosis / pathology

A 28-year-old woman with prior neurosurgery involving the placement of a cadaveric dural graft developed a rapidly progressive neurodegenerative disorder with prominent cerebellar dysfunction that was proven at autopsy to be Creutzfeldt-Jakob disease. She represents the second American to develop Creutzfeldt-Jakob disease in association with a dural graft. The unusual features of the case include the patient's initial clinical presentation with cerebellar ataxia in the absence of dementia, the widespread presence of kuru-type amyloid plaques on a histological examination of the brain, the development of clinical symptoms during pregnancy, and the subsequent delivery of a child who remains healthy at the age of 3 years.

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