Malignant neoplasms following cardiac transplantation

TitleMalignant neoplasms following cardiac transplantation
Publication TypeJournal Article
Year of Publication1978
AuthorsKrikorian JG, Anderson JL, Bieber CP, Penn I, Stinson EB
Pagination639 - 43
Date PublishedAug 18
Accession Number353312
Keywords*Heart Transplantation, *Postoperative Complications, Adolescent, Adult, Colonic Neoplasms / etiology, Humans, Immunosuppression / *adverse effects, Leukemia / etiology, Lymphoma / etiology, Middle Aged, Neoplasms / *etiology, Research Support, U.S. Gov't, P.H.S., risk, Skin Neoplasms / etiology, Transplantation, Homologous

Between Jan 6, 1968, and April 11, 1977, 124 patients underwent cardiac transplantation at Stanford University Medical Center, with a mean and median period of follow-up of 18.3 and 9.7 months, respectively. Malignant neoplasms developed in seven patients--three lymphoproliferative neoplasms, two skin cancers, one acute leukemia, and one colon carcinoma. Visceral tumors were often fatal and caused 11% of deaths after three months following transplantation. The incidence and spectrum of malignant neoplasms in this population are similar to those observed in recipients of renal homografts.

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