Human cyclic neutropenia transferred by allogeneic bone marrow grafting

TitleHuman cyclic neutropenia transferred by allogeneic bone marrow grafting
Publication TypeJournal Article
Year of Publication1982
AuthorsKrance RA, Spruce WE, Forman SJ, Rosen RB, Hecht T, Hammond WP, Blume KG
Pagination1263 - 6
Date PublishedDec
Type of ArticleCase Reports Research Support, U.S. Gov't, P.H.S.
ISSN0006-4971 (Print) 0006-4971 (Linking)
Accession Number6753968
Keywords*Bone Marrow Transplantation, *Periodicity, Agranulocytosis / *etiology, Animals, Child, Preschool, Dogs, Humans, Leukemia, Lymphoid / complications / therapy, Neutropenia / *etiology / genetics, Pedigree, Transplantation, Homologous / *adverse effects

Human cyclic neutropenia shows many features in common with the animal model of cyclic neutropenia in grey collie dogs. Until now, however, evidence was lacking that cyclic neutropenia in man as in the dog is caused by a defect in a transplantable hematopoietic stem cell. A patient is presented who, while undergoing bone marrow transplantation as treatment for acute lymphoblastic leukemia in relapse, acquired cyclic neutropenia from her histocompatible sibling donor.

Alternate JournalBlood
Notify Library Reference ID832

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