| Title | Acanthamoeba infection in a patient with chronic graft-versus-host disease occurring during treatment with voriconazole. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Kaul DR, Lowe L, Visvesvara GS, Farmen S, Khaled YA, Yanik GA |
| Journal | Transpl Infect Dis |
| Volume | 10 |
| Issue | 6 |
| Pagination | 437 - 41 |
| Date Published | Dec |
| ISSN | 1399-3062 |
| Accession Number | 18713138 |
| Keywords | Acanthamoeba, Amebiasis, Animals, Antifungal Agents, Antiprotozoal Agents, Drug Therapy, Combination, Encephalitis, Fatal Outcome, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Lung, Male, Middle Aged, Phosphorylcholine, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Pyrimidines, Skin, Triazoles |
| Abstract | We report a case of disseminated infection with Acanthamoeba in a patient with graft-versus-host disease after hematopoietic stem cell transplant (HSCT) for acute lymphocytic leukemia. The infection involved the brain, skin, and lungs and occurred despite treatment with voriconazole for mold prophylaxis, and did not respond to treatment with multiple other agents reported to have activity against Acanthamoeba. To our knowledge, infection with Acanthamoeba has been reported in 4 other patients after HSCT or bone marrow transplant, and our case is the first to be diagnosed ante-mortem. |
| DOI | 10.1111/j.1399-3062.2008.00335.x |
| Notify Library Reference ID | 774 |
