Hepatitis G virus does not cause significant liver disease after liver transplantation

TitleHepatitis G virus does not cause significant liver disease after liver transplantation
Publication TypeJournal Article
Year of Publication1998
AuthorsKarayiannis P, Brind AM, Pickering J, Mathew J, Burt AD, Hess G, Bassendine MF, Thomas HC
JournalJournal of viral hepatitis
Pagination35 - 42
Date PublishedJan
ISSN1352-0504 (Print) 1352-0504 (Linking)
Accession Number9493515
KeywordsAlanine Transaminase / metabolism, Bile Ducts / cytology / pathology, Biopsy, Blood Transfusion / adverse effects, Epithelial Cells / pathology, Female, Flaviviridae / genetics / immunology / *isolation & purification, Hepatitis Antibodies / analysis / immunology, Hepatitis, Viral, Human / *diagnosis / epidemiology / immunology, Humans, Immunocompromised Host, Liver / physiology / virology, Liver Transplantation / *adverse effects, Male, Polymerase Chain Reaction, Prevalence, RNA, Viral / *isolation & purification, Viremia / diagnosis

The aim of this study was to determine the prevalence of infection with the newly described hepatitis G virus (HGV) in a liver transplant cohort, and to establish the frequency and nature of hepatitis in those with and without HGV infection. A reverse transcriptase-polymerase chain reaction technique was employed to determine viraemia in the patients, and liver biopsies taken at different times after transplantation were assessed histologically. Hepatitis G virus RNA was detected in 47% of the liver transplant recipients investigated. Those positive for HGV had received significantly more blood or blood products than the HGV-negative patients. The frequency of abnormal liver function tests was similar in HGV-positive and HGV-negative recipients. Bile duct epithelial cell damage was more frequently seen in those with HGV viraemia. This study indicates that almost half of the liver transplant recipients in Northern England are positive for HGV, and that infection is associated with exposure to blood and blood products. It appears that, in the immunosuppressed patient, HGV does not cause clinically significant liver disease, at least up to 2 years after transplantation. If HGV infection is associated with hepatitis outside this clinical setting, it is likely that the liver damage is immunopathologically mediated rather than as a result of direct viral cytotoxicity.

Alternate JournalJ Viral Hepat
Notify Library Reference ID759

Related Incidents