Cross-Canada spread of methicillin-resistant Staphylococcus aureus via transplant organs

TitleCross-Canada spread of methicillin-resistant Staphylococcus aureus via transplant organs
Publication TypeJournal Article
Year of Publication1999
AuthorsJohnston L, Chui L, Chang N, Macdonald S, McKenzie M, Kennedy W, Haldane D, Bethune R, Taylor G, Hanakowski M, Tyrrell G
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Pagination819 - 23
Date PublishedOct
ISSN1058-4838 (Print) 1058-4838 (Linking)
Accession Number10589896
Keywords*Methicillin Resistance, Adolescent, Canada, Female, Humans, Infant, Kidney Transplantation / *adverse effects, Liver Transplantation / *adverse effects, Male, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Staphylococcal Infections / *transmission, Staphylococcus aureus / drug effects / *isolation & purification, Tissue Donors

We report our investigation of the transmission of methicillin-resistant Staphylococcus aureus (MRSA) through transplantation. The kidneys, liver, and corneas were harvested from a child who died in Nova Scotia. Several days postmortem it was learned that culture of a premortem endotracheal tube aspirate from the donor yielded MRSA. Both kidneys were transplanted into a child in Nova Scotia and the liver into a child in Alberta. Both recipients subsequently became blood culture-positive for MRSA. One corneal ring from the donor was MRSA-positive. All four MRSA isolates were mecA-positive by polymerase chain reaction (PCR). The relatedness of the MRSA isolates was examined by restriction fragment length polymorphism (RFLP) analysis, a 16S-23S ribosomal PCR typing method, and comparison of antibiograms. Results were identical for all four MRSA isolates. These findings indicate that MRSA from the donor was transferred to recipients during implantation of harvested organs in Alberta and Nova Scotia, a cross-Canada spread.

Alternate JournalClin Infect Dis
Notify Library Reference ID745

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