The risk of cytomegalovirus transmission by penetrating keratoplasty

TitleThe risk of cytomegalovirus transmission by penetrating keratoplasty
Publication TypeJournal Article
Year of Publication1988
AuthorsHolland EJ, Bennett SR, Brannian R, Osborne JC, Goeken JA, Krachmer JH
JournalAm J Ophthalmol
Volume105
Issue4
Pagination357 - 60
Date Published42095
ISSN0002-9394 (Print) 0002-9394 (Linking)
Accession Number2833856
Keywords*Corneal Transplantation, Aged, Antibodies, Viral / analysis, Cornea / microbiology, Cytomegalovirus / immunology, Cytomegalovirus Infections / *transmission, Humans, Immune Tolerance, Middle Aged, Risk Factors, Serologic Tests, Tissue Donors
Abstract

To investigate the risk of cytomegalovirus transmission by corneal transplantation, we quantitated anticytomegalovirus IgG levels of donor, preoperative, and postoperative serum samples. Of 118 patients, 79 (67%) were seropositive preoperatively. Twenty-five patients who were seronegative preoperatively received a graft from a positive donor and two (8%) seroconverted. Eleven patients who were seronegative preoperatively received a graft from a negative donor and one (9%) seroconverted. None of the patients who seroconverted had a febrile illness and all three grafts were clear.
URLinternal-pdf://Holland - risk of CMV transmission-3717019393/Holland - risk of CMV transmission.pdf
Notify Library Reference ID686

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