Acquired hemophilia A after liver transplantation: a case report

TitleAcquired hemophilia A after liver transplantation: a case report
Publication TypeJournal Article
Year of Publication2003
AuthorsHisatake GM, Chen TW, Renz JF, Farmer DG, Ghobrial RM, Yersiz H, Amado RG, Goldstein L, Busuttil RW
JournalLiver Transpl
Pagination523 - 6
Date PublishedMay
ISSN1527-6465 (Print) 1527-6465 (Linking)
Accession Number12740798
KeywordsFactor VIII / metabolism, Hemophilia A / *etiology, Hepatitis C, Chronic / *surgery, Humans, Liver Transplantation / *adverse effects, Male, Middle Aged, Postoperative Complications, Tissue Donors

It is well recognized that orthotopic liver transplantation rapidly corrects the coagulation disorder observed in patients with hemophilia A or B combined with end-stage liver disease; however, the transmission of hemophilia from a donor to a transplant recipient has not been reported previously. We describe a patient who developed acquired hemophilia A after liver transplantation due to the unknown presence of factor VIII inhibitor in the donor. The resulting coagulation disorder was unresponsive to standard factor replacement therapy, and was ultimately corrected with retransplantation. Hemophiliac donors should not be precluded from organ donation, though the presence of factor VIII inhibitor should be actively sought before organ procurement. High levels of factor VIII inhibitor represents an absolute contraindication to liver donation.

DOI10.1053/jlts.2003.50095 S1527646503500296 [pii]
Notify Library Reference ID673

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