Infectious disease risk factors of corneal graft donors

TitleInfectious disease risk factors of corneal graft donors
Publication TypeJournal Article
Year of Publication2008
AuthorsHassan SS, Wilhelmus KR, Dahl P, Davis GC, Roberts RT, Ross KW, Varnum BH
JournalArchives of ophthalmology
Pagination235 - 9
Date PublishedFeb
Type of ArticleResearch Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
ISSN0003-9950 (Print) 0003-9950 (Linking)
Accession Number18268215
Keywords*Cornea, *Disease Transmission, Infectious, *Postoperative Complications, *Tissue Donors, Adult, Aged, Case-Control Studies, Cause of Death, Confidence Intervals, Endophthalmitis / microbiology / *transmission, Eye Banks / statistics & numerical data, Eye Infections / microbiology / *transmission, Health Status, Humans, Keratoplasty, Penetrating / *adverse effects, Middle Aged, Odds Ratio, Population Surveillance, Registries / statistics & numerical data, Risk Factors, United States

OBJECTIVE: To determine how donor health status affects the risk of infection after corneal transplant. METHODS: An adverse reaction surveillance registry was used to conduct a matched case-control study among transplanted donor corneas from January 1, 1994, to December 31, 2003. Cases comprised 162 reports of endophthalmitis after penetrating keratoplasty including 121 with microbial recovery, of which 59 had concordant donor and recipient microbial isolates. Two controls were matched to each case by surgery date. Conditional logistic regression estimated adjusted odds ratios with 95% confidence intervals according to the premortem status of decedent donors. RESULTS: Postkeratoplasty endophthalmitis was associated with recent hospitalization (odds ratio, 2.84; 95% confidence interval, 1.61-4.98) and fatal cancer (odds ratio, 2.46; 95% confidence interval, 1.53-3.97) among donors. Endophthalmitis appeared more likely with tissues transplanted longer than 5 days after donation (odds ratio, 1.55; 95% confidence interval, 1.02-2.35). The prevalence of concordant microbial isolates from donors and recipients was greater among fungal endophthalmitis than among bacterial endophthalmitis (P

Alternate JournalArch Ophthalmol
Notify Library Reference ID650

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