| Title | Genomic allelotyping for distinction of recurrent and de novo hepatocellular carcinoma after orthotopic liver transplantation |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Altimari A, Gruppioni E, Fiorentino M, Petraroli R, Pinna AD, Petropulacos K, Ridolfi L, Costa AN, Grigioni WF, Grigioni AD |
| Journal | Diagnostic molecular pathology : the American journal of surgical pathology, part B |
| Volume | 14 |
| Issue | 1 |
| Pagination | 34 - 8 |
| Date Published | Mar |
| Type of Article | Case Reports Comparative Study Research Support, Non-U.S. Gov't |
| ISSN | 1052-9551 (Print) 1052-9551 (Linking) |
| Accession Number | 15714062 |
| Keywords | *Liver Transplantation, Adult, Alleles, Carcinoma, Hepatocellular / diagnosis / *genetics / *surgery, DNA, Neoplasm / genetics, Female, Genotype, Humans, Liver Neoplasms / diagnosis / *genetics / *surgery, Male, Middle Aged, Neoplasm Recurrence, Local / *diagnosis / *genetics, Polymerase Chain Reaction, Tandem Repeat Sequences |
| Abstract | Distinction between recurrent and de novo hepatocellular carcinoma (HCC) after orthotopic liver transplantation (OLT) bears important clinical and therapeutic implications. Techniques for molecular profiling of clinically suspected de novo and recurrent HCC are required since the histological/clinical discrimination of donor vs. recipient tumor origin is difficult. Multiple PCR amplification of 16 highly polymorphic short tandem repeat (STR) DNA sequences (routinely used for paternity and forensic assays) was applied in two patients who developed a second HCC after OLT. In both patients the technique provided reliable evidence that the two second HCC were recurrences of the primary tumor. Multiple STR genetic allelotyping is an effective tool for clear-cut discrimination of donor/recipient origin of a second HCC after OLT. Its application could be of great therapeutic relevance for such OLT patients. |
| Alternate Journal | Diagn Mol Pathol |
| Notify Library Reference ID | 59 |
