Bone substitutes: an update

TitleBone substitutes: an update
Publication TypeJournal Article
Year of Publication2005
AuthorsGiannoudis PV, Dinopoulos H, Tsiridis E
Volume36 Suppl 3
PaginationS20 - 7
Date PublishedNov
Accession Number16188545
KeywordsBone Cements / therapeutic use, Bone Substitutes / *therapeutic use, Bone Transplantation / *methods, Ceramics / therapeutic use, Collagen / therapeutic use, Durapatite / therapeutic use, Humans, Transplantation, Autologous, Transplantation, Homologous

Autograft is considered ideal for grafting procedures, providing osteoinductive growth factors, osteogenic cells, and an osteoconductive scaffold. Limitations, however, exist regarding donor site morbidity and graft availability. Allograft on the other hand, posses the risk of disease transmission. Synthetic graft substitutes lack osteoinductive or osteogenic properties. Composite grafts combine scaffolding properties with biological elements to stimulate cell proliferation and differentiation and eventually osteogenesis. We present here an overview of bone grafts and graft substitutes available for clinical applications.

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