Long-term follow-up of patients with osteochondral allografts. A correlation between immunologic responses and clinical outcome

TitleLong-term follow-up of patients with osteochondral allografts. A correlation between immunologic responses and clinical outcome
Publication TypeJournal Article
Year of Publication1999
AuthorsFriedlaender GE, Strong DM, Tomford WW, Mankin HJ
JournalOrthop Clin North Am
Volume30
Issue4
Pagination583 - 8
Date PublishedOct
ISSN0030-5898 (Print) 0030-5898 (Linking)
Accession Number10471763
KeywordsAnimals, Bone Transplantation / *immunology, Cartilage / *transplantation, Cryopreservation, Disease Models, Animal, Follow-Up Studies, Histocompatibility / immunology, Histocompatibility Antigens Class I / immunology, Histocompatibility Antigens Class II / immunology, Humans, Immunization, Longitudinal Studies, Transplantation, Homologous, Treatment Outcome
Abstract

This article confirms immunologic responses in humans to histocompatibility antigens (Class I and II) presented by frozen osteochondral allografts. These observations include a correlation of immune responses with long-term clinical outcome. As found in animal models, matching of histocompatibility antigens, particularly to Class II, improves clinical and, presumably, biologic success following implantation of massive frozen bone allografts in humans. The presence of sensitization clearly does not preclude a satisfactory outcome, nor have other reconstructive alternatives (e.g., metallic implants) been shown to be superior in their long-term results.

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