| Title | First report of donor cell-derived acute leukemia as a complication of umbilical cord blood transplantation |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Fraser CJ, Hirsch BA, Dayton V, Creer MH, Neglia JP, Wagner JE, Baker KS |
| Journal | Blood |
| Volume | 106 |
| Issue | 13 |
| Pagination | 4377 - 80 |
| Date Published | Dec 15 |
| ISSN | 0006-4971 (Print) 0006-4971 (Linking) |
| Accession Number | 16118319 |
| Keywords | *Blood Donors, *Umbilical Cord, Acute Disease, Chromosomes, Human, Pair 22 / genetics, Cord Blood Stem Cell Transplantation / *adverse effects, Cytogenetics, Humans, Infant, Leukemia / *etiology / genetics / *pathology, Male |
| Abstract | Donor cell leukemia is a rare complication after allogeneic hematopoietic stem cell transplantation. A 12-month-old boy underwent unrelated donor umbilical cord blood transplant (UCBT) for refractory Langerhan's cell histiocytosis. Forty months after transplantation, he developed acute myeloid leukemia. Cytogenetic and molecular analysis confirmed donor cell origin. The Cord Blood Bank (CBB) contacted the donor's family and established that the child, now 7 years old, was healthy. This represents the first reported case of donor cell leukemia following UCBT. This case illustrates that donor cell leukemia is a rare but real event after UCBT as with other stem cell sources and highlights the need for CBBs to maintain linkage data between donors and recipients. |
| DOI | 10.1182/blood-2005-06-2551 |
| Notify Library Reference ID | 543 |
