Severe CD4+ T-cell lymphopenia is not observed in frequent plateletpheresis donors collected on the Fenwal Amicus

TitleSevere CD4+ T-cell lymphopenia is not observed in frequent plateletpheresis donors collected on the Fenwal Amicus
Publication TypeJournal Article
Year of Publication2019
AuthorsGansner JM, Papari M, Goldstein J, Gaufberg RA, Neuberg D, Makar RS, Kaufman RM
Volume59
Issue9
Pagination3
Date PublishedSep
Abstract

Background: In a recent study, we determined that 30% of frequent plateletpheresis donors collected using the Trima Accel Automated Blood Collection System (Terumo BCT) had a CD4+ T-cell count below 200 cells/μL. Whether CD4+ T-cell lymphopenia is associated with donation using other plateletpheresis instruments is unknown.

Study design and methods: We obtained blood samples from 30 current frequent Fenwal Amicus plateletpheresis donors. All participants had made 20 to 24 plateletpheresis donations in the most recent 365-day period, and all had previously donated over 50 times on the Fenwal Amicus instrument. Blood samples were analyzed to determine blood counts, including CD4+ and CD8+ counts.

Results: Of 30 study participants, none had a CD4+ count below 200 cells/μL. There was one participant with a CD4+ count between 200 and 300 cells/μL. This individual was over the age of 55 and had a history of more than 300 lifetime plateletpheresis sessions. One participant had a CD8+ count below the lower limit of normal (125 cells/μL) and a normal CD4+ count.

Conclusion: We did not detect severe CD4+ lymphopenia in frequent platelet donors undergoing plateletpheresis with the Fenwal Amicus. Since the Fenwal Amicus does not incorporate a leukoreduction system chamber, this finding supports the hypothesis that such chambers-found in the Trima Accel instrument-contribute to CD4+ lymphopenia in frequent platelet donors.

DOI10.1111/trf.15441
Alternate JournalTransfusion
Notify Library Reference ID5009

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