Ureaplasma Transmitted From Donor Lungs Is Pathogenic After Lung Transplantation

TitleUreaplasma Transmitted From Donor Lungs Is Pathogenic After Lung Transplantation
Publication TypeJournal Article
Year of Publication2017
AuthorsFernandez R, Ratliff A, Crabb D, Waites KB, Bharat A
Volume103
Issue2
Date PublishedFeb
Abstract

Hyperammonemia is a highly fatal syndrome in lung recipients that is usually refractory to medical therapy. We recently reported that infection by a Mollicute, Ureaplasma, is causative for hyperammonemia and can be successfully treated with antimicrobial agents. However, it remains unknown whether the pathogenic strain of Ureaplasma is donor or recipient derived. Here we provide evidence that donor-derived Ureaplasma infection can be pathogenic. As such, we uncover a previously unknown lethal donor-derived opportunistic infection in lung recipients. Given the high mortality associated with hyperammonemia, strategies for routine donor screening or prophylaxis should be further evaluated in prospective studies.

DOI10.1016/j.athoracsur.2016.09.026
Alternate JournalAnn Thorac Surg
Notify Library Reference ID4861

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