|Title||A cluster of donor-derived Cryptococcus neoformans infection affecting lung, liver, and kidney transplant recipients: Case report and review of literature|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Camargo JF, Simkins J, Schain DC, Gonzalez AA, Alcaide ML, Anjan S, Guerra G, Roth D, Kupin WL, Mattiazzi A, Tan Y, Milikowski C, Morris MI, Abbo LM|
Donor-derived infections (DDIs) are a very rare but potentially devastating complication of solid organ transplantation. Here we present a cluster of proven donor-derived cryptococcal infection in the kidney, liver, and lung recipients from a single donor. Remarkably, the onset of illness in the kidney and liver recipients occurred more than 8-12 weeks after transplantation, which is beyond the incubation period previously reported for donor-derived cryptococcosis. DDI should always be considered in the differential diagnosis of transplant recipients admitted with febrile illness, even when presenting beyond the first month post-transplant. Communication between reference laboratories, transplant centers, and organ procurement organizations is critical to improve outcomes.
|Alternate Journal||Transpl Infect Dis.|
|Notify Library Reference ID||4791|