Title | A cluster of donor-derived Cryptococcus neoformans infection affecting lung, liver, and kidney transplant recipients: Case report and review of literature |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Camargo JF, Simkins J, Schain DC, Gonzalez AA, Alcaide ML, Anjan S, Guerra G, Roth D, Kupin WL, Mattiazzi A, Tan Y, Milikowski C, Morris MI, Abbo LM |
Volume | 20 |
Issue | 2 |
Pagination | e12836 |
Date Published | Apr |
Abstract | Donor-derived infections (DDIs) are a very rare but potentially devastating complication of solid organ transplantation. Here we present a cluster of proven donor-derived cryptococcal infection in the kidney, liver, and lung recipients from a single donor. Remarkably, the onset of illness in the kidney and liver recipients occurred more than 8-12 weeks after transplantation, which is beyond the incubation period previously reported for donor-derived cryptococcosis. DDI should always be considered in the differential diagnosis of transplant recipients admitted with febrile illness, even when presenting beyond the first month post-transplant. Communication between reference laboratories, transplant centers, and organ procurement organizations is critical to improve outcomes. |
DOI | 10.1111/tid.12836 |
Alternate Journal | Transpl Infect Dis. |
Notify Library Reference ID | 4791 |
A cluster of donor-derived Cryptococcus neoformans infection affecting lung, liver, and kidney transplant recipients: Case report and review of literature
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