|Title||Transmission of Babesia microti Parasites by Solid Organ Transplantation|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Brennan MB, Herwaldt BL, Kazmierczak JJ, Weiss JW, Klein CL, Leith CP, He R, Oberley MJ, Tonnetti L, Wilkins PP, Gauthier GM|
|Keywords||Babesia microti, Babesiosis, Erythrocyte Transfusion, hemolytic anemia, human babesiosis, kidney transplant, Minnesota, Organ Transplantation, parasites, protozoa, tissue donor, United States, vector-borne infections, Wisconsin|
Babesia microti, an intraerythrocytic parasite, is tickborne in nature. In contrast to transmission by blood transfusion, which has been well documented, transmission associated with solid organ transplantation has not been reported. We describe parasitologically confirmed cases of babesiosis diagnosed ≈8 weeks posttransplantation in 2 recipients of renal allografts from an organ donor who was multiply transfused on the day he died from traumatic injuries. The organ donor and recipients had no identified risk factors for tickborne infection. Antibodies against B. microti parasites were not detected by serologic testing of archived pretransplant specimens. However, 1 of the organ donor's blood donors was seropositive when tested postdonation and had risk factors for tick exposure. The organ donor probably served as a conduit of Babesia parasites from the seropositive blood donor to both kidney recipients. Babesiosis should be included in the differential diagnosis of unexplained fever and hemolytic anemia after blood transfusion or organ transplantation.
|Alternate Journal||Emerg Infect Dis|
|Notify Library Reference ID||4623|