Granulocyte colony-stimulating factor administration: adverse events

TitleGranulocyte colony-stimulating factor administration: adverse events
Publication TypeJournal Article
Year of Publication2008
AuthorsD'Souza A, Jaiyesimi I, Trainor L, Venuturumili P
JournalTransfusion Medicine Reviews
Pagination280 - 90
Keywords*Granulocyte Colony-Stimulating Factor / ae [Adverse Effects], *Granulocyte Colony-Stimulating Factor / tu [Therapeutic Use], Blood Donors, Bone and Bones / de [Drug Effects], Bone Marrow / de [Drug Effects], Cardiovascular Diseases / ci [Chemically Induced], Drug Hypersensitivity / ep [Epidemiology], Granulocyte Colony-Stimulating Factor / ad [Administration & Dosage], Hematologic Diseases / ci [Chemically Induced], Hematopoietic Stem Cell Transplantation / ae [Adverse Effects], Hematopoietic Stem Cell Transplantation / mt [Methods], Humans, Kidney Diseases / ci [Chemically Induced], Lung Diseases / ci [Chemically Induced], Neoplasms / ci [Chemically Induced], Rheumatic Diseases / ci [Chemically Induced], Skin Diseases / ci [Chemically Induced], Thyroid Diseases / ci [Chemically Induced]

Recombinant human granulocyte colony-stimulating factor (G-CSF) has been in clinical use for approximately 2 decades. In healthy donors, it has been used to mobilize peripheral blood progenitor cells for hematopoietic stem cell transplantation and granulocytes for apheresis collection. In patients, it has been used to decrease the duration of neutropenia after chemotherapy and to offset the neutropenia due to myelodysplasia, acquired immunodeficiency syndrome, and genetic disorders of granulocyte production. As the number of uses of G-CSF in clinical practice grows, more side effects of this generally safe pharmaceutical agent are being recognized. Our objective in this article is to provide an in-depth review of the reported adverse events associated with the use of G-CSF. [References: 112]

Short TitleGranulocyte colony-stimulating factor administration: adverse events
Notify Library Reference ID457

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