Transmission of GB virus type C via transfusion in a cohort of HIV-infected patients.

TitleTransmission of GB virus type C via transfusion in a cohort of HIV-infected patients.
Publication TypeJournal Article
Year of Publication2012
AuthorsVahidnia F, Petersen M, Rutherford G, Busch M, Assmann S, Stapleton JT, Custer B
JournalThe Journal of infectious diseases// J Infect Dis
Pagination1436 - 42
Date Published2012//
ISBN Number1537-6613
Other Numbersih3, 0413675
Keywords*Blood Transfusion/ae [Adverse Effects], *Flaviviridae Infections/tm [Transmission], *GB virus C/py [Pathogenicity], *HIV Infections/co [Complications], Adult, Antibodies, Viral, CD4 Lymphocyte Count, Female, Flaviviridae Infections/co [Complications], Flaviviridae Infections/vi [Virology], Follow-Up Studies, GB virus C/ip [Isolation & Purification], HIV Infections/tm [Transmission], HIV Infections/vi [Virology], HIV/ip [Isolation & Purification], HIV/py [Pathogenicity], Humans, Logistic Models, Male, Prospective Studies, RNA, Viral/ip [Isolation & Purification], Viral Load, Virus Activation

BACKGROUND: GB virus C (GBV-C) infection is transmitted by blood exposure and associated with lower human immunodeficiency virus (HIV) load and slower HIV disease progression. Few studies describe predictors of acute GBV-C infection following transfusion in HIV-infected patients., METHODS: We used a limited-access database from the National Heart Lung and Blood Institute's Viral Activation Transfusion Study, a randomized controlled trial of leukoreduced versus nonleukoreduced transfusions received by HIV-infected, transfusion-naive patients. Blood samples from 489 subjects were tested for GBV-C markers in pretransfusion and posttransfusion samples. We estimated the risk of acquiring GBV-C RNA and predictors of GBV-C acquisition, using pooled logistic regression., RESULTS: GBV-C RNA was detected

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