Human herpesvirus 8 transfusion transmission in Ghana, an endemic region of West Africa.

TitleHuman herpesvirus 8 transfusion transmission in Ghana, an endemic region of West Africa.
Publication TypeJournal Article
Year of Publication2012
AuthorsGobbini F, Owusu-Ofori S, Marcelin A-, Candotti D, Allain J-
JournalTransfusion// Transfusion
Pagination2294 - 9
Date Published2012//
ISBN Number1537-2995
Other Numberswdn, 0417360
Keywords*Blood Transfusion/ae [Adverse Effects], *Blood Transfusion/sn [Statistics & Numerical Data], *Endemic Diseases/sn [Statistics & Numerical Data], *Herpesviridae Infections, *Herpesvirus 8, Human/ge [Genetics], Antibodies, Viral/bl [Blood], Blood Donors/sn [Statistics & Numerical Data], Genotype, Ghana/ep [Epidemiology], Guinea/ep [Epidemiology], Herpesviridae Infections/bl [Blood], Herpesviridae Infections/ep [Epidemiology], Herpesviridae Infections/tm [Transmission], Herpesvirus 8, Human/cl [Classification], Herpesvirus 8, Human/im [Immunology], Humans, Phylogeny, Risk Factors, Seroepidemiologic Studies

BACKGROUND: Human herpesvirus 8 (HHV-8) seroprevalence ranges between less than 5% in Europe and North America and 50% to 70% in sub-Saharan Africa. Evidence of HHV-8 transfusion transmission is only indirect. We conducted a serologic (anti-HHV-8) and molecular (HHV-8 DNA) study of samples from paired donor-immunocompetent recipients transfused with whole blood., STUDY DESIGN AND METHODS: Samples from 252 donor-recipient pairs were tested. Immunoglobulin G to HHV-8 was detected with enzyme immunoassays and confirmed with an in-house immunofluorescence assay. The cellular fraction from seroreactive donors and their recipients was tested for HHV-8 DNA., RESULTS: Anti-HHV-8 was positive (reactive in two or more assays) in 28 (11%) patients and 16 (6%) donors. Of 12 seronegative recipients (at risk of transmission) receiving seropositive blood, one very likely transmission was identified (8.3% confidence interval, 0%-23%). The donor blood contained HHV-8 DNA and his and four other donors' sequences clustered separately from recorded genotypes with a 97% bootstrap constituting a distinct genotype., CONCLUSIONS: HHV-8 is transmitted in Ghana but does not carry clinical consequences since most patients are immunocompetent. The clinical risk will increase with the availability of immunosuppressive drugs in sub-Saharan Africa. We propose that a new genotype (HHV-8-G for Ghana) be added to the current nomenclature.Copyright © 2012 American Association of Blood Banks.

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