Title | Occult hepatitis B virus infection as a cause of posttransfusion hepatitis in patients with cancers. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Sodhi JS, Wani N, Jeelani S, Geelani S, Akhtar F, Javid G, Yattoo GN, Shah A, Gulzar GM, Khan MA, Parveen S, Saif R-, Showkat A |
Journal | Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology// Indian J Gastroenterol |
Volume | 32 |
Issue | 5 |
Pagination | 291 - 6 |
Date Published | 2013// |
ISBN Number | 0975-0711 |
Other Numbers | gja, 8409436 |
Keywords | *Blood Transfusion/ae [Adverse Effects], *Hepatitis B/ep [Epidemiology], *Neoplasms/th [Therapy], Adolescent, Adult, Aged, Blood Safety, Child, DNA, Viral/bl [Blood], Female, Hepatitis B Surface Antigens/bl [Blood], Hepatitis B virus/ge [Genetics], Hepatitis B virus/im [Immunology], Hepatitis B/im [Immunology], Hepatitis B/tm [Transmission], Humans, Incidence, India/ep [Epidemiology], Male, Middle Aged, Seroepidemiologic Studies, Young Adult |
Abstract | BACKGROUND: Prevalence of hepatitis B virus (HBV) infection is increased in patients of cancer with increased mortality. Multiple transfusions of blood and blood-related products are a potential source., AIMS: This study aims to assess the incidence of hepatitis B surface antigen (HBsAg) seroconversion in cancer patients receiving transfusion of blood or blood-related products and identify possible reasons for infection in these patients., MATERIAL AND METHODS: Patients of cancer receiving blood products, who were HBsAg-, anti-hepatitis B core (HBc)-, and HBV DNA-negative prior to transfusion, were tested for HBsAg by ELISA at 6, 12, and 24 weeks after the last transfusion. Blood donors were screened for HBsAg by ELISA., RESULTS: Twenty of 3,600 (0.56 %) blood donors tested positive for HBsAg and were rejected. Nine of 150 (6 %) cancer patients became HBsAg-positive posttransfusion which included seven patients who presented with acute hepatitis B and other two patients who remained HBsAg-positive without hepatitis. In 6/9 (66.6 %) patients, HBsAg positivity was related to blood transfusion as their corresponding blood donors on retesting the stored samples were positive for anti-HBc antibody and HBV DNA. In other three patients, the cause of their HBsAg positivity could not be ascertained., CONCLUSION: Occult HBV infection in blood donors is a potential source of posttransfusion HBV infection in recipients. Anti-HBc antibody and HBV DNA should be tested in blood donors especially when blood is given to cancer patients receiving chemotherapy. |
Notify Library Reference ID | 4536 |
Occult hepatitis B virus infection as a cause of posttransfusion hepatitis in patients with cancers.
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