Infectivity of blood products from donors with occult hepatitis B virus infection.

TitleInfectivity of blood products from donors with occult hepatitis B virus infection.
Publication TypeJournal Article
Year of Publication2013
AuthorsAllain J-, Mihaljevic I, Gonzalez-Fraile MI, Gubbe K, Holm-Harritshoj L, Garcia JM, Brojer E, Erikstrup C, Saniewski M, Wernish L, Bianco L, Ullum H, Candotti D, Lelie N, Gerlich WH, Chudy M
JournalTransfusion// Transfusion
Pagination1405 - 15
Date Published2013//
ISBN Number1537-2995
Other Numberswdn, 0417360
Keywords*Blood Donors, *Blood Transfusion/ae [Adverse Effects], *Hepatitis B/tm [Transmission], Adult, Aged, Female, Hepatitis B Antibodies/bl [Blood], Hepatitis B virus/ge [Genetics], Humans, Male, Middle Aged, Mutation, Risk Factors

BACKGROUND: Occult hepatitis B virus (HBV) infection (OBI) is identified in 1:1000 to 1:50,000 European blood donations. This study intended to determine the infectivity of blood products from OBI donors., STUDY DESIGN AND METHODS: Recipients of previous donations from OBI donors were investigated through lookback (systematic retrieval of recipients) or traceback (triggered by clinical cases). Serologic and genomic studies were undertaken on consenting donors and recipients. Multiple variables potentially affecting infectivity were examined., RESULTS: A total of 45 of 105 (42.9%) donor-recipients pairs carried antibodies to HBV core (anti-HBc) as evidence of previous HBV infection. Subtracting 15% of anti-HBc population background, the adjusted transmission rate was 28%. Anti-HBc prevalence increased to 28 of 44 (63.8%) in unvaccinated recipients receiving anti-HBs-negative OBI blood products. In contrast, four of 26 (15.4%) recipients of anti-HBs-positive products were anti-HBc positive. Transmission with anti-HBs-negative products depended on volume of plasma transfused (85%-100% with 200 mL of fresh frozen plasma [FFP], 51% with 50 mL in platelet concentrates [PCs], and 24% with 20 mL in red blood cells [RBCs], p

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