Blood transfusion and breast milk transmission of cytomegalovirus in very low-birth-weight infants: a prospective cohort study.

TitleBlood transfusion and breast milk transmission of cytomegalovirus in very low-birth-weight infants: a prospective cohort study.
Publication TypeJournal Article
Year of Publication2014
AuthorsJosephson CD, Caliendo AM, Easley KA, Knezevic A, Shenvi N, Hinkes MT, Patel RM, Hillyer CD, Roback JD
JournalJAMA pediatrics// Jama, Pediatr.
Volume168
Issue11
Pagination1054 - 62
Date Published2014//
ISBN Number2168-6211
Other Numbers101589544
Keywords*Blood Transfusion/ae [Adverse Effects], *Cytomegalovirus Infections/tm [Transmission], *Cytomegalovirus/ip [Isolation & Purification], *Infant, Newborn, Diseases/et [Etiology], *Infant, Very Low Birth Weight, *Milk, Human/mi [Microbiology], Cohort Studies, Female, Humans, Infant, Newborn, Male, Proportional Hazards Models, Prospective Studies, Risk Factors
Abstract

IMPORTANCE: Postnatal cytomegalovirus (CMV) infection can cause serious morbidity and mortality in very low-birth-weight (VLBW) infants. The primary sources of postnatal CMV infection in this population are breast milk and blood transfusion. The current risks attributable to these vectors, as well as the efficacy of approaches to prevent CMV transmission, are poorly characterized., OBJECTIVE: To estimate the risk of postnatal CMV transmission from 2 sources: (1) transfusion of CMV-seronegative and leukoreduced blood and (2) maternal breast milk., DESIGN, SETTING, AND PARTICIPANTS: A prospective, multicenter birth-cohort study was conducted from January 2010 to June 2013 at 3 neonatal intensive care units (2 academically affiliated and 1 private) in Atlanta, Georgia. Cytomegalovirus serologic testing of enrolled mothers was performed to determine their status. Cytomegalovirus nucleic acid testing (NAT) of transfused blood components and breast milk was performed to identify sources of CMV transmission. A total of 539 VLBW infants (birth weight,

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