Title | Blood transfusion and breast milk transmission of cytomegalovirus in very low-birth-weight infants: a prospective cohort study. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Josephson CD, Caliendo AM, Easley KA, Knezevic A, Shenvi N, Hinkes MT, Patel RM, Hillyer CD, Roback JD |
Journal | JAMA pediatrics// Jama, Pediatr. |
Volume | 168 |
Issue | 11 |
Pagination | 1054 - 62 |
Date Published | 2014// |
ISBN Number | 2168-6211 |
Other Numbers | 101589544 |
Keywords | *Blood Transfusion/ae [Adverse Effects], *Cytomegalovirus Infections/tm [Transmission], *Cytomegalovirus/ip [Isolation & Purification], *Infant, Newborn, Diseases/et [Etiology], *Infant, Very Low Birth Weight, *Milk, Human/mi [Microbiology], Cohort Studies, Female, Humans, Infant, Newborn, Male, Proportional Hazards Models, Prospective Studies, Risk Factors |
Abstract | IMPORTANCE: Postnatal cytomegalovirus (CMV) infection can cause serious morbidity and mortality in very low-birth-weight (VLBW) infants. The primary sources of postnatal CMV infection in this population are breast milk and blood transfusion. The current risks attributable to these vectors, as well as the efficacy of approaches to prevent CMV transmission, are poorly characterized., OBJECTIVE: To estimate the risk of postnatal CMV transmission from 2 sources: (1) transfusion of CMV-seronegative and leukoreduced blood and (2) maternal breast milk., DESIGN, SETTING, AND PARTICIPANTS: A prospective, multicenter birth-cohort study was conducted from January 2010 to June 2013 at 3 neonatal intensive care units (2 academically affiliated and 1 private) in Atlanta, Georgia. Cytomegalovirus serologic testing of enrolled mothers was performed to determine their status. Cytomegalovirus nucleic acid testing (NAT) of transfused blood components and breast milk was performed to identify sources of CMV transmission. A total of 539 VLBW infants (birth weight, |
Notify Library Reference ID | 4526 |
Blood transfusion and breast milk transmission of cytomegalovirus in very low-birth-weight infants: a prospective cohort study.
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