Delayed seroconversion and rapid onset of lymphoproliferative disease after transmission of human T-cell lymphotropic virus type 1 from a multiorgan donor.

TitleDelayed seroconversion and rapid onset of lymphoproliferative disease after transmission of human T-cell lymphotropic virus type 1 from a multiorgan donor.
Publication TypeJournal Article
Year of Publication2013
AuthorsGlowacka I, Korn K, Potthoff SA, Lehmann U, Kreipe HH, Ivens K, Barg-Hock H, Schulz TF, Heim A
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America// Clin Infect Dis
Volume57
Issue10
Pagination1417 - 24
Date Published2013//
ISBN Number1537-6591
Other Numbersa4j, 9203213
Keywords*Antibodies, Viral/bl [Blood], *HTLV-I Infections/vi [Virology], *Human T-lymphotropic virus 1/ip [Isolation & Purification], *Lymphoma/vi [Virology], *Transplantation/ae [Adverse Effects], DNA, Viral/an [Analysis], Female, HTLV-I Infections/bl [Blood], Humans, Lymphoma/bl [Blood], Male, Middle Aged, Skin/ch [Chemistry], Skin/im [Immunology], Tissue Donors
Abstract

BACKGROUND: Human T-cell lymphotropic virus type 1 (HTLV-1) screening of blood and organ donors is not mandatory in Germany because of its low prevalence (about 7/100 000). An HTLV-1 transmission event caused by a multiple organ donor was investigated. Validity of diagnostic procedures and HTLV-1 disease association in immunosuppressed organ recipients were analyzed., METHODS: Two screening immunoassays and an immunoblot (confirmatory assay) were used for detection of HLTV-1/2 antibodies. Proviral DNA was quantified in blood and biopsies of organ recipients by HTLV-1 real-time polymerase chain reaction (PCR)., RESULTS: Proviral HTLV-1-DNA was detected in all blood samples of 3 organ recipients (1-100 copies/10(2) cells), but seroconversion was delayed for up to 2 years in screening assays and >6 years in the confirmatory assay. In 2 of 3 organ recipients, a cutaneous T-cell lymphoma was diagnosed 2 and 3 years after infection, respectively. Proviral HTLV-1 DNA concentration was almost 100 copies/10(2) cells in cutaneous lymphoma biopsies whereas in biopsies of other tissues

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