Risk of squamous cell skin cancer after organ transplant associated with antibodies to cutaneous papillomaviruses, polyomaviruses, and TMC6/8 (EVER1/2) variants.

TitleRisk of squamous cell skin cancer after organ transplant associated with antibodies to cutaneous papillomaviruses, polyomaviruses, and TMC6/8 (EVER1/2) variants.
Publication TypeJournal Article
Year of Publication2014
AuthorsMadeleine MM, Carter JJ, Johnson LG, Wipf GC, Davis C, Berg D, Nelson K, Daling JR, Schwartz SM, Galloway DA
JournalCancer medicine// Cancer Med
Volume3
Issue5
Pagination1440 - 7
Date Published2014//
ISBN Number2045-7634
Other Numbers101595310
Keywords*Carcinoma, Squamous Cell/et [Etiology], *Genetic Variation, *Organ Transplantation/ae [Adverse Effects], *Papillomaviridae/ge [Genetics], *Papillomavirus Infections/co [Complications], *Skin Neoplasms/et [Etiology], Carcinoma, Squamous Cell/ep [Epidemiology], Case-Control Studies, Genotype, Humans, Odds Ratio, Papillomaviridae/cl [Classification], risk, Skin Neoplasms/ep [Epidemiology]
Abstract

Squamous cell skin cancer (SCSC) disproportionately affects organ transplant recipients, and may be related to increased viral replication in the setting of immune suppression. We conducted a nested case-control study among transplant recipients to determine whether SCSC is associated with antibodies to cutaneous human papillomaviruses (HPV), to genes associated with a rare genetic susceptibility to HPV (TMC6/TMC8), or to human polyomaviruses (HPyV). Cases (n = 149) had histologically confirmed SCSC, and controls (n = 290) were individually matched to cases on time since transplant, type of transplant, gender, and race. All subjects had serum drawn immediately prior to transplant surgery. Antibodies to 25 cutaneous HPVs and six HPyVs were assayed by detection of binding to virus-like particles, and 11 TMC6/8 variants were genotyped. After correction for multiple comparisons, only antibodies to HPV37 were associated with SCSC (OR 2.0, 95% CI 1.2-3.4). Common genetic variants of TMC6/8 were not associated with SCSC, but three variants in TMC8 (rs12452890, rs412611, and rs7208422) were associated with greater seropositivity for species 2 betapapillomaviruses among controls. This study suggests that some betaHPVs, but not polyomaviruses, may play a role in the excess risk of SCSC among transplant recipients. Copyright © 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

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