First report of Babesia divergens infection in an HIV patient.

TitleFirst report of Babesia divergens infection in an HIV patient.
Publication TypeJournal Article
Year of Publication2015
AuthorsGonzalez LM, Castro E, Lobo CA, Richart A, Ramiro R, Gonzalez-Camacho F, Luque D, Velasco AC, Montero E
JournalInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases// Int J Infect Dis
Pagination202 - 4
Date Published2015//
ISBN Number1878-3511
Other Numbersc3r, 9610933
Keywords*Babesia/ip [Isolation & Purification], *Babesiosis/di [Diagnosis], *Coinfection/di [Diagnosis], *HIV Infections/co [Complications], Adult, Babesiosis/et [Etiology], Blood Donors, Blood Transfusion, Humans, Male, Retrospective Studies, Splenectomy

Human babesiosis is a zoonosis primarily transmitted through Ixodes ticks and alternatively by routes such as blood transfusions from asymptomatic donors. We report the first case of human babesiosis caused by Babesia divergens in a patient with HIV. This study also focuses on elucidating the possible transmission route of infection in this patient, who received numerous blood transfusions but showed patent symptoms only after splenectomy. A battery of detection tools along with a novel Western-Blot Assay and Enzyme Linked Immunosorbent Assay using the major surface protein of B. divergens (Bd37) as a target were used to evaluate the presence of B. divergens or antibodies against the parasite in samples from the patient and the blood donors involved in this case. A retrospective study of the humoral status against the parasite revealed B. divergens IgG antibodies in one of the implicated donors, but also showed that the patient had been already exposed to the parasite before any transfusion. Thus, this analysis of natural and transfusion transmission routes suggests a pre-existing subclinical babesiosis in the patient. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

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