Splenic rupture in a parental donor undergoing peripheral blood progenitor cell mobilization

TitleSplenic rupture in a parental donor undergoing peripheral blood progenitor cell mobilization
Publication TypeJournal Article
Year of Publication2004
AuthorsDincer AP, Gottschall J, Margolis DA
JournalJ Pediatr Hematol Oncol
Volume26
Issue11
Pagination761 - 3
Date PublishedNov
ISSN1077-4114 (Print) 1077-4114 (Linking)
Accession Number15543014
Keywords*Tissue Donors, Adult, Granulocyte Colony-Stimulating Factor / adverse effects, Hematopoietic Stem Cell Mobilization / *adverse effects, Humans, Male, Parents, Peripheral Blood Stem Cell Transplantation, Spleen / blood supply / pathology, Splenic Rupture / *etiology
Abstract

Peripheral blood progenitor cells (PBPCs) are now widely used as a source of progenitor cells for allogeneic transplantation. Recombinant human granulocyte colony-stimulating factor is used to mobilize PBPCs for collection by leukapheresis. Although side effects of mobilization are generally benign, adverse effects have been reported. The authors present a case of spontaneous splenic rupture, without splenomegaly, in a parental donor undergoing PBPC mobilization, review the literature regarding this adverse event, and explore issues regarding donor safety.
DOI
Notify Library Reference ID443

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