Hemolysis due to the simultaneous occurrence of passenger lymphocyte syndrome and a delayed hemolytic transfusion reaction in a liver transplant patient.

TitleHemolysis due to the simultaneous occurrence of passenger lymphocyte syndrome and a delayed hemolytic transfusion reaction in a liver transplant patient.
Publication TypeJournal Article
Year of Publication1996
AuthorsJacobs LB, Shirey RS, Ness PM
JournalArchives of pathology & laboratory medicine//Arch Pathol Lab Med
Volume120
Issue7
Pagination684 - 6
Date Published1996
ISBN Number0003-9985
Other Numbers79z, 7607091
Keywords*Anemia, Hemolytic/et [Etiology], *B-Lymphocytes/im [Immunology], *Erythrocyte Transfusion/ae [Adverse Effects], *Erythrocytes/im [Immunology], *Liver Transplantation/im [Immunology], ABO Blood-Group System/im [Immunology], Blood Group Incompatibility/im [Immunology], Humans, Isoantibodies/an [Analysis], Male, Middle Aged, Transplantation Immunology
Abstract

Hemolysis due to donor-derived antibodies produced by "passenger" B lymphocytes, called passenger lymphocyte syndrome, has been described in ABO-unmatched solid organ and bone marrow transplant recipients. Delayed hemolytic transfusion reactions occur within a similar time frame and have similar clinical and serologic findings. To our knowledge, we report the first case of hemolysis due to the simultaneous occurrence of passenger lymphocyte syndrome (donor-derived anti-A) and a delayed hemolytic transfusion reaction (recipient-produced anti-E) in a liver transplant patient.
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