Anti-Dob implicated as the cause of a delayed hemolytic transfusion reaction.

TitleAnti-Dob implicated as the cause of a delayed hemolytic transfusion reaction.
Publication TypeJournal Article
Year of Publication1985
AuthorsMoheng MC, McCarthy P, Pierce SR
JournalTransfusion//Transfusion
Volume25
Issue1
Pagination44 - 6
Date Published1985
ISBN Number0041-1132
Other Numberswdn, 0417360
Keywords*Blood Group Antigens/im [Immunology], *Blood Transfusion/ae [Adverse Effects], *Hemolysis, *Isoantibodies/ad [Administration & Dosage], Adult, Antigen-Antibody Reactions, Blood Grouping and Crossmatching, Coombs Test, Female, Humans, Isoantibodies/an [Analysis], Isoantibodies/ph [Physiology], Time Factors
Abstract

A 27-year-old, gravida 3, para 2 woman experienced a delayed hemolytic transfusion reaction. She had anti-Dob in both serum and eluate 8 days after infusion of 6 units of Do(b+) red cells. No antibody had been detected prior to transfusion. By the 15th day after transfusion, there was no evidence of survival of red cells from any of the 6 units. Anti-C and anti-M were demonstrated later, but 29 months after transfusion, no atypical antibodies were detectable. The evidence suggests anti-Dob should be considered an antibody of potential clinical significance until contrary evidence becomes available.

Notify Library Reference ID4394