Multiorgan transplantation from a deceased donor with intravascular diffuse large B-cell lymphoma: transmission of the disease and results of treatment.

TitleMultiorgan transplantation from a deceased donor with intravascular diffuse large B-cell lymphoma: transmission of the disease and results of treatment.
Publication TypeJournal Article
Year of Publication2014
AuthorsDziewanowski K, Drozd R, Parczewski M, Klinke M
Journal//Clin Transplant
Volume28
Issue10
Pagination1080 - 1083
Date Published2014
ISBN Number0902-0063
Other Numbersbb5, 8710240
Keywordsdiffuse large B-cell lymphoma, Kidney Transplantation, Liver Transplantation, transplant complications
Abstract

: This report presents the transplantation of two kidneys and the liver from a deceased donor with suspected autoimmune encephalomeningitis (ADEM). Due to an atypical post-transplantation clinical course, the transplanted kidneys were biopsied and this disclosed diffuse large B-cell (DLBC) lymphoma of the intravascular type in each kidney. The same malignancy was found in the postmortem donor brain examination. The renal allografts from the two recipients were removed: despite every effort, one patient died, while chemotherapy was successful in the second. No malignancy was observed in the liver transplant recipient, who received prophylactic chemotherapy. These cases highlight the occasional failure of organ donor disease screening and the consequent unforeseen complications., (C) 2014 John Wiley & Sons, Ltd

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