Vitiligo following a combined liver-kidney transplant.

TitleVitiligo following a combined liver-kidney transplant.
Publication TypeJournal Article
Year of Publication2009
AuthorsBradley V, Kemp EH, Dickinson C, Key T, Gibbs P, Clatworthy MR
JournalNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association//Nephrol Dial Transplant
Pagination686 - 8
Date Published2009
ISBN Number1460-2385
Other Numbersn7j, 8706402
Keywords*Kidney Transplantation/ae [Adverse Effects], *Liver Transplantation/ae [Adverse Effects], *Vitiligo/et [Etiology], Autoimmunity, Humans, Isoantibodies/me [Metabolism], Kidney Transplantation/im [Immunology], Liver Transplantation/im [Immunology], Male, Melanocytes/im [Immunology], Middle Aged, T-Lymphocytes, Cytotoxic/im [Immunology], T-Lymphocytes, Cytotoxic/tr [Transplantation], Time Factors, Tissue Donors, Vitiligo/im [Immunology]

We report an Afro-Caribbean male who developed vitiligo 10 days following a combined liver-kidney transplant from a Caucasian donor. Neither the donor nor the recipient had any previous history of vitiligo, nor of autoimmunity. The depigmentation gradually resolved by 8 weeks post-transplant with topical corticosteroids and standard maintenance immunosuppression. We propose that the skin depigmentation occurred due to the destruction of melanocytes by donor-derived alloreactive cytotoxic T-lymphocytes or antibody transferred during transplantation. Although vitiligo has been described in patients receiving allogeneic bone marrow transplantation for haematological malignancy, there are no previous reports of vitiligo post-solid organ transplantation.

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