Characterizing the Epidemiology of Perioperative Transfusion-associated Circulatory Overload.

TitleCharacterizing the Epidemiology of Perioperative Transfusion-associated Circulatory Overload.
Publication TypeJournal Article
Year of Publication2015
AuthorsClifford L, Jia Q, Yadav H, Subramanian A, Wilson G, Murphy S, Pathak J, Schroeder D, Ereth M, Kor D
Pagination21 - 28
Date Published2015
ISBN Number0003-3022
Other Numbers4sg, 1300217

Background: Transfusion-associated circulatory overload (TACO) is a leading cause of transfusion-related fatalities, but its incidence and associated patient and transfusion characteristics are poorly understood. To inform surgical transfusion practice and to begin mitigating perioperative TACO, the authors aimed to define its epidemiology., Methods: In this retrospective cohort study, the medical records of adult patients undergoing noncardiac surgery with general anesthesia during 2004 or 2011 and receiving intraoperative transfusions were screened using an electronic algorithm for identification of TACO. Those patients who were screened as high probability for TACO underwent rigorous manual review. Univariate and multivariate analyses evaluated associations between patient and transfusion characteristics with TACO rates in a before-and-after study design., Results: A total of 2,162 and 1,908 patients met study criteria for 2004 and 2011, respectively. The incidence of TACO was 5.5% (119 of 2,162) in 2004 versus 3.0% (57 of 1,908) in 2011 (P

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