Asymptomatic transmission of Treponema pallidum (syphilis) through deceased donor liver transplantation.

TitleAsymptomatic transmission of Treponema pallidum (syphilis) through deceased donor liver transplantation.
Publication TypeJournal Article
Year of Publication2012
AuthorsTariciotti L., Das I., Dori L., Perera M., Bramhall S.
Journal//Transpl Infect Dis
Pagination321 - 325
Date Published2012
ISBN Number1398-2273
Other Numbersd1d, 100883688
Keywordsdonor-transmitted infections, high-risk donor, Liver Transplantation, Syphilis, Treponema pallidum

colon; A 55-year-old woman underwent liver transplantation (LT) with a graft from a deceased donor. Mandatory pre-donation investigations showed positive syphilis serology that was available only after the transplant, with high Treponema pallidum particle agglutination assay titer compatible with donor syphilis infection. Despite the institution of appropriate post-exposure prophylaxis, the recipient demonstrated latent seroconversion; however, liver graft function improved without evidence of syphilitic hepatitis or other manifestations of the disease. Through this first reported case of asymptomatic transmission of syphilis following LT, we highlight the investigations and treatment strategies for donor-derived syphilis in liver transplant recipients. This report supplements the existing limited evidence on safe use of infected grafts from syphilitic donors through appropriate post-exposure prophylaxis., Copyright (C) 2012 Blackwell Publishing Ltd.

Notify Library Reference ID4271

Related Incidents