Prevention of toxoplasmosis in transplant patients

TitlePrevention of toxoplasmosis in transplant patients
Publication TypeJournal Article
Year of Publication2008
AuthorsDerouin F, Pelloux H
JournalClin Microbiol Infect
Pagination1089 - 101
Date PublishedDec
ISSN1469-0691 (Electronic) 1198-743X (Linking)
Accession Number19018809
Keywords*Transplantation, control / transmission, Disease Transmission, Infectious / *prevention & control, Humans, Toxoplasmosis / epidemiology / physiopathology / *prevention &

Toxoplasmosis is a life-threatening opportunistic infection that affects haematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT) recipients. Its incidence in these patients is closely related to the prevalence of toxoplasmosis in the general population, which is high in Europe. In SOT recipients, toxoplasmosis results mainly from transmission of the parasite with the transplanted organ from a Toxoplasma-seropositive donor to a Toxoplasma-seronegative recipient. This risk is high in cases of transplantation of organs that are recognized sites of encystation of the parasite, e.g. the heart, and is markedly lower in other SOT recipients. Clinical symptoms usually occur within the first 3 months after transplantation, sometimes as early as 2 weeks post transplant, and involve febrile myocarditis, encephalitis or pneumonitis. In HSCT recipients, the major risk of toxoplasmosis results from the reactivation of a pre-transplant latent infection in seropositive recipients. The median point of disease onset is estimated at 2 months post transplant, with

Notify Library Reference ID427

Related Incidents