Title | Acute hemolytic transfusion reaction secondary to anti-Fy3. |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Olteanu H, Gerber D, Partridge K, Sarode R |
Journal | Immunohematology / American Red Cross//IMMUNOHEMATOLOGY |
Volume | 21 |
Issue | 2 |
Pagination | 48 - 52 |
Date Published | 2005 |
ISBN Number | 0894-203X |
Other Numbers | 8806387 |
Keywords | *Blood Transfusion/ae [Adverse Effects], *Hemolysis/im [Immunology], *Isoantibodies/bl [Blood], Acute Disease, Aged, Aged, 80 and over, Female, Humans, Isoantibodies/im [Immunology], Phenotype |
Abstract | A hemolytic transfusion reaction due to anti-Fy3 is reported in an African American patient with no history of sickle cell disease. This 82-year-old African American woman received two units of RBCs for anemia (Hab 7 g/dL) on admission for a left hip fracture. On hospital Day 7, the patient underwent left hip endoprosthesis surgery; she received two units of RBCs on the second postoperative day due to Hb of 6.1 g/dL. Her urine was dark during surgery and postoperatively. Her posttransfusion plasma was red. Her Hb dropped from 8.4 to 6.4 g/dL over 24 hours after the transfusion. Her total bilirubin rose to 4.0 mg/dL, with and LDH value of 1558 U/L and a haptoglobin of 10.9 mg/dL. Both the antibody detection test and the DAT were positive. An anti-Fy3 was identified in the serum and in the eluate. To the best of our knowledge, this is the first case of acute intravascular hemolysis due to anti-Fy3 in a patient without sickle cell disease. |
Notify Library Reference ID | 4242 |
Acute hemolytic transfusion reaction secondary to anti-Fy3.
Related Incidents
- 1252 - Acute Hemolytic Transfusion Reaction (AHTR), anti-Fy3 - Red blood cells