An unusual case of an acute hemolytic transfusion reaction caused by an autoanti-I.

TitleAn unusual case of an acute hemolytic transfusion reaction caused by an autoanti-I.
Publication TypeJournal Article
Year of Publication2011
AuthorsWin N, Needs M, Rahman S, Gold P, Ward S
JournalImmunohematology / American Red Cross//IMMUNOHEMATOLOGY
Volume27
Issue3
Pagination101 - 3
Date Published2011
ISBN Number1930-3955
Other Numbers8806387
Keywords*Anemia, Hemolytic, Autoimmune/bl [Blood], *Anemia, Hemolytic, Autoimmune/im [Immunology], *Autoantibodies/bl [Blood], *Blood Group Incompatibility/bl [Blood], *Cold Temperature/ae [Adverse Effects], *I Blood-Group System/im [Immunology], Acute Disease, Autoantibodies/ae [Adverse Effects], Blood Group Incompatibility/co [Complications], Blood Grouping and Crossmatching, Cells, Cultured, Child, False Positive Reactions, Guidelines as Topic, Humans, Male, Protein Binding, Reproducibility of Results
Abstract

In general, naturally occurring cold autoagglutinins react optimally at low temperatures. We describe a young child who experienced an acute hemolytic transfusion reaction by an unusual autoanti-I. The IgM autoanti-I was detected at 4degreeC (titer 256) and also reacted at 30degreeC. This case highlights the potential hazard of transfusing units of blood immediately upon removal from the blood refrigerator, especially into neonates and children of small stature.
Notify Library Reference ID4241