Acute Hemolytic Transfusion Reaction in a Pediatric Patient Following Transfusion of Apheresis Platelets.

TitleAcute Hemolytic Transfusion Reaction in a Pediatric Patient Following Transfusion of Apheresis Platelets.
Publication TypeJournal Article
Year of Publication2005
AuthorsSapatnekar S, Sharma G, Downes K, Wiersma S, McGrath C, Yomtovian R
Volume20
Issue4
Pagination225 - 229
Date Published2005
ISBN Number0733-2459
KeywordsABO blood groups, Hemolysis, Platelet Transfusion
Abstract

: The practice of transfusing ABO-incompatible platelets, driven primarily by concerns about inventory management, has been considered generally safe because the accompanying plasma is usually diluted in the recipient's total blood volume. However, if the platelet product contains a large volume of plasma or a high concentration of incompatible isoagglutinin, there may be hemolysis of the recipient's red cells. Patients with a small blood volume, such as babies and children, are considered to be at particular risk for such a complication. We describe the case of a baby who suffered massive hemolysis of her group A red cells after transfusion of group O Apheresis Platelets containing a high-titered anti-A isoagglutinin. We also offer a review of the literature on this subject and recommendations to avoid acute hemolytic reactions as a result of platelet transfusion., Copyright (C) 2005 John Wiley & Sons, Inc.

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