Transfer of vitiligo after allogeneic bone marrow transplantation

TitleTransfer of vitiligo after allogeneic bone marrow transplantation
Publication TypeJournal Article
Year of Publication2002
AuthorsAlajlan A, Alfadley A, Pedersen KT
JournalJ Am Acad Dermatol
Pagination606 - 10
Date PublishedApr
ISSN0190-9622 (Print) 0190-9622 (Linking)
Accession Number11907519
KeywordsAdult, Bone Marrow Transplantation / *adverse effects / immunology, Graft vs Host Disease / immunology / pathology, Humans, Immunization, Passive, Living Donors, Male, Multiple Myeloma / *therapy, Vitiligo / *etiology / immunology

Adoptive transfer of donor immunity has been demonstrated in animals after bone marrow transplantation (BMT). In humans, several autoimmune diseases have been similarly transferred. Although BMT may, per se, be associated with a modulation of the recipient's immune system, which could trigger or even cause autoimmune diseases, both animal experiments and experience with humans show the likeliness of adoptive transfer of donor immunity to the recipient. We describe a patient with multiple myeloma in whom generalized vitiligo developed within 3 months after allogeneic BMT from his HLA-matched sister with vitiligo. We believe that a form of adoptive transfer of donor immunity to the recipient might play a role in the development of vitiligo. In spite of this, neither de novo development of vitiligo in a genetically predisposed patient nor autoimmune phenomena associated with graft-versus-host disease can be completely excluded as a contributing factor for development of vitiligo in our patient. To our knowledge, this is the first case report of transfer of vitiligo after BMT from a donor with vitiligo.

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