Severe hemolytic transfusion reaction due to anti-D in a D+ patient with sickle cell disease.

TitleSevere hemolytic transfusion reaction due to anti-D in a D+ patient with sickle cell disease.
Publication TypeJournal Article
Year of Publication2015
AuthorsIpe TS, Wilkes JJ, Hartung HD, Westhoff CM, Chou ST, Friedman DF
JournalJournal of pediatric hematology/oncology//J Pediatr Hematol Oncol
Volume37
Issue2
Paginatione135 - 7
Date Published2015
ISBN Number1536-3678
Other Numbers9505928, b57
Abstract

A 5-year-old male with sickle cell disease presented with pain, dark urine, and fatigue 10 days after a red blood cell (RBC) transfusion. Laboratory evaluation demonstrated severe anemia, blood type O+, and anti-D in the serum. Anti-D in a D+ patient led to RH genotyping, which revealed homozygosity for RHD*DAU4 that encodes partial D antigen. Anti-D in this patient whose RBCs exclusively express partial D caused a delayed hemolytic transfusion reaction after exposure to D+ RBCs. The finding of anti-D in a D+patient should be investigated by molecular methods to help distinguish an alloantibody from an autoantibody.

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