Acquired immunodeficiency syndrome (AIDS) associated with transfusions.

TitleAcquired immunodeficiency syndrome (AIDS) associated with transfusions.
Publication TypeJournal Article
Year of Publication1984
AuthorsCurran JW, Lawrence DN, Jaffe H, Kaplan JE, Zyla LD, Chamberland M, Weinstein R, Lui KJ, Schonberger LB, Spira TJ
JournalThe New England journal of medicine//N Engl J Med
Pagination69 - 75
Date Published1984
ISBN Number0028-4793
Other Numbers0255562, now
Keywords*Acquired Immunodeficiency Syndrome/tm [Transmission], *Blood Transfusion/ae [Adverse Effects], Acquired Immunodeficiency Syndrome/ep [Epidemiology], Adult, Aged, Blood Donors, Female, Humans, Male, Mathematics, Middle Aged, Models, Biological, Pneumonia, Pneumocystis/et [Etiology], risk, T-Lymphocytes/im [Immunology], United States

Of 2157 patients with the acquired immunodeficiency syndrome (AIDS) whose cases were reported to the Centers for Disease Control by August 22, 1983, 64 (3 per cent) with AIDS and Pneumocystis carinii pneumonia had no recognized risk factors for AIDS. Eighteen of these (28 per cent) had received blood components within five years before the onset of illness. These patients with transfusion-associated AIDS were more likely to be white (P = 0.00008) and older (P = 0.0013) than other patients with no known risk factors. They had received blood 15 to 57 months (median, 27.5) before the diagnosis of AIDS, from 2 to 48 donors (median, 14). At least one high-risk donor was identified by interview or T-cell-subset analysis in each of the seven cases in which investigation of the donors was complete; five of the six high-risk donors identified during interview also had low T-cell helper/suppressor ratios, and four had generalized lymphadenopathy according to history or examination. These findings strengthen the evidence that AIDS may be transmitted in blood.

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