Solid cancers after bone marrow transplantation

TitleSolid cancers after bone marrow transplantation
Publication TypeJournal Article
Year of Publication1997
AuthorsCurtis RE, Rowlings PA, Deeg HJ, Shriner DA, Socie G, Travis LB, Horowitz MM, Witherspoon RP, Hoover RN, Sobocinski KA, F., Fraumeni J. J, D., Roberts J. J
JournalN Engl J Med
Pagination897 - 904
Date Published46447
Accession Number9070469
KeywordsAdolescent, Adult, Age Factors, Analysis of Variance, Bone Marrow Transplantation / *adverse effects, Child, Female, Follow-Up Studies, Graft vs Host Disease / complications, Hematologic Diseases / therapy, Humans, Incidence, Leukemia / therapy, Male, Neoplasms, Radiation-Induced / etiology, Neoplasms, Second Primary / epidemiology / *etiology, Radiation Dosage, Regression Analysis, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Risk Factors, Time Factors, Whole-Body Irradiation / adverse effects

BACKGROUND: The late effects of bone marrow transplantation, including cancer, need to be determined in a large population at risk. METHODS: We studied 19,229 patients who received allogeneic transplants (97.2 percent) or syngeneic transplants (2.8 percent) between 1964 and 1992 at 235 centers to evaluate the risk of the development of a new solid cancer. Risk factors relating to the patient, the transplant, and the course after transplantation were evaluated. RESULTS: The transplant recipients were at significantly higher risk of new solid cancers than the general population (observed cases, 80; ratio of observed to expected cases, 2.7; P

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