Relapse into blast crisis following bone marrow transplantation for chronic phase chronic myeloid leukaemia: a report of five cases

TitleRelapse into blast crisis following bone marrow transplantation for chronic phase chronic myeloid leukaemia: a report of five cases
Publication TypeJournal Article
Year of Publication1992
AuthorsCullis JO, Marks DI, Schwarer AP, Barrett AJ, Hows JM, Swirsky DM, Goldman JM
JournalBr J Haematol
Volume81
Issue3
Pagination378 - 82
Date PublishedJul
Accession Number1390210
KeywordsAdult, Blast Crisis / *etiology, Bone Marrow Transplantation / *adverse effects, Female, Humans, Leukemia, Myeloid, Chronic / *surgery, Male, Recurrence
Abstract

A proportion of patients receiving allogeneic bone marrow transplants (BMT) for chronic myeloid leukaemia (CML) in first chronic phase relapse; most of these relapses show features of chronic phase disease. We report here a series of five patients seen at a single institution over a 10 year period who developed blast crisis as the first sign of relapse after BMT for CML in chronic phase. The blast cells were myeloid in three cases and lymphoid in two. In one case the relapse may have occurred in cells of donor origin. The possible explanations for this unusual sequence of events include incipient transformation that was not detected before BMT, undetected relapse into chronic phase proceeding into transformation post-BMT, and transformation occurring de novo post-BMT in small numbers of residual leukaemic stem cells.

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