Creutzfeldt-Jakob disease after liver transplantation

TitleCreutzfeldt-Jakob disease after liver transplantation
Publication TypeJournal Article
Year of Publication1995
AuthorsCreange A, Gray F, Cesaro P, Adle-Biassette H, Duvoux C, Cherqui D, Bell J, Parchi P, Gambetti P, Degos JD
JournalAnn Neurol
Pagination269 - 72
Date PublishedAug
ISSN0364-5134 (Print) 0364-5134 (Linking)
Accession Number7654078
Keywords*Liver Transplantation, Creutzfeldt-Jakob Syndrome / *etiology / pathology, Endopeptidase K, Female, Humans, Iatrogenic Disease, Middle Aged, Postoperative Complications, Prions / genetics, Serine Endopeptidases

We report a 57-year-old woman who died from Creutzfeldt-Jakob disease 2 years after a liver transplantation. The liver donor had no history of neurological disease. In one albumin donor, possible Creutzfeldt-Jakob disease developed 3 years later. The patient initially had cerebellar symptoms. Neuropathology included "Kuru-type" plaques and prion protein (PrP) deposits involving the cerebellum predominantly. The patient was homozygote valine at codon 129 of the PrP gene while the liver was homozygote methionine. This observation raises the possibility of transmission of Creutzfeldt-Jakob disease by the graft itself or the associated albumin transfusions and, on a wider extent, by nonneural tissue.

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