Diffuse alveolar hemorrhage following autologous bone marrow infusion

TitleDiffuse alveolar hemorrhage following autologous bone marrow infusion
Publication TypeJournal Article
Year of Publication1993
AuthorsCorso S, Vukelja SJ, Wiener D, Baker WJ
JournalBone Marrow Transplantation
Pagination301 - 3
Date PublishedSep
Type of ArticleCase Reports
ISSN0268-3369 (Print) 0268-3369 (Linking)
Accession Number8241990
KeywordsAnoxia / etiology, Antineoplastic Combined Chemotherapy Protocols / therapeutic use, Bone Marrow Transplantation / *adverse effects, Combined Modality Therapy, Cryopreservation, Dimethyl Sulfoxide / adverse effects, Dyspnea / etiology, Fatal Outcome, Female, Hemorrhage / *etiology / pathology, Humans, Lung Diseases / *etiology / pathology, Lymphoma, Large B-Cell, Diffuse / drug therapy / *surgery, Middle Aged, Pulmonary Alveoli / pathology, Thrombocytopenia / therapy, Tissue Preservation, Transplantation, Autologous / adverse effects

Autologous BMT performed in a 57-year-old woman with relapsed large cell lymphoma was complicated by two consecutive episodes of diffuse alveolar hemorrhage (DAH). The second episode occurred immediately after infusion of autologous BM. DAH is an increasingly recognized complication of autologous BMT and carries a high mortality. It is characterized by dyspnea, cough, bilateral pulmonary infiltrates and progressively bloodier aliquots of bronchoalveolar lavage fluid. The pathogenesis is probably multifactorial involving an initial insult to lung endothelium with inflammatory cells serving as the mediators of subsequent injury. The rapid development of DAH following marrow infusion strongly implicates DMSO as a potential cause in our patient.

Alternate JournalBone Marrow Transplant
Notify Library Reference ID374

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