|Title||The longest survivor and first potential cure of an advanced cholangiocarcinoma by ex vivo resection and autotransplantation: a case report and review of the literature|
|Publication Type||Journal Article|
|Year of Publication||2003|
|Authors||Chui AK, Island ER, Rao AR, Lau WY|
|Pagination||441 - 4|
|Keywords||*Survivors, Adult, Bile Duct Neoplasms / *surgery, Bile Ducts, Intrahepatic / *surgery, Cholangiocarcinoma / *surgery, Female, Hepatic Duct, Common / *surgery, Humans, Klatskin's Tumor / *surgery, Liver Transplantation / *methods, Transplantation, Autologous / *methods|
Bismuth type IV hilar cholangiocarcinoma (CC) carries a poor prognosis; however, ex vivo liver resection and autotransplantation (Atx) is theoretically a treatment option. There are only five previously reported cases of this procedure for hilar CC in the English literature, and most of them died early in the postoperative period. The only reported survivor died of tumor recurrence at 13 months. We are reporting a patient who has survived for 17 months without any sign of tumor recurrence. This probably represents the world's first cure for CC using this technique. This patient is a 26-year-old woman with a Bismuth Type IV CC. Portal vein involvement at the confluence was shown on angiogram, and in situ resection was deemed impossible. Ex vivo resection of segments five, six, seven, eight, and part of segment four was performed followed by a partial liver Atx. The pathology specimen demonstrated CC with clear margins. MRI and CT examinations done over the subsequent 17 months showed no evidence of recurrence. In conclusion ex vivo liver resection and Atx can be a viable option for cure among highly selected patients with CC.
|Notify Library Reference ID||343|