Endophthalmitis from contaminated donor corneas following penetrating keratoplasty

TitleEndophthalmitis from contaminated donor corneas following penetrating keratoplasty
Publication TypeJournal Article
Year of Publication1991
AuthorsCameron JA, Antonios SR, Cotter JB, Habash NR
JournalArch Ophthalmol
Pagination54 - 9
Date PublishedJan
ISSN0003-9950 (Print) 0003-9950 (Linking)
Accession Number1987949
Keywords*Tissue Donors, Adolescent, Adult, Aged, Aged, 80 and over, Bacteria / drug effects, Cornea / microbiology, Drug Resistance, Microbial, Endophthalmitis / *etiology / pathology, Eye Banks, Eye Infections, Bacterial / *etiology / pathology, Eye Infections, Fungal / *etiology / pathology, Female, Fungi / drug effects, Gentamicins / pharmacology, Humans, Keratoplasty, Penetrating / *adverse effects, Male, Middle Aged

We encountered six (0.2%) cases of endophthalmitis resulting from contaminated donor corneas between January 1983 and July 1990 following a total of 3000 consecutive penetrating keratoplasties. Causative organisms in the three cases of fungal endophthalmitis were Torulopsis glabrata, Candida albicans, and Aspergillus flavus; the three cases of bacterial endophthalmitis were due to Klebsiella pneumoniae, Staphylococcus aureus, and Enterococcus faecalis. All organisms were resistant to gentamicin in the preservation media. A significantly higher incidence of endophthalmitis was noted in patients receiving corneas from a Sri Lankan eye bank (1.25%) than in those receiving US eye bank tissue (0.14%). Donor rim cultures are important to identify those patients at increased risk of developing endophthalmitis, enabling earlier diagnosis and more specific treatment should endophthalmitis occur.

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